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Glufosinate-ammonium
CASRN 77182-82-2
Contents
0247
Glufosinate-ammonium; CASRN 77182-82-2
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Glufosinate-ammonium
File On-Line 09/30/1987
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) on-line 05/01/1992
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) no data
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- Glufosinate-ammonium
CASRN -- 77182-82-2
Primary Synonym -- Hoe 39866
Last Revised -- 05/01/1992
The oral Reference Dose (RfD) is based on the assumption that thresholds exist
for certain toxic effects such as cellular necrosis. It is expressed in units
of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning
perhaps an order of magnitude) of a daily exposure to the human population
(including sensitive subgroups) that is likely to be without an appreciable
risk of deleterious effects during a lifetime. Please refer to the Background
Document for an elaboration of these concepts. RfDs can also be derived for
the noncarcinogenic health effects of substances that are also carcinogens.
Therefore, it is essential to refer to other sources of information concerning
the carcinogenicity of this substance. If the U.S. EPA has evaluated this
substance for potential human carcinogenicity, a summary of that evaluation
will be contained in Section II of this file.
NOTE: The Oral RfD for glufosinate-ammonium may change in the near future
pending the outcome of a further review now being conducted by the RfD/RfC
Work Group.
___I.A.1. ORAL RfD SUMMARY
Critical Effect Experimental Doses* UF MF RfD
-------------------- ----------------------- ----- --- ---------
Increased absolute NOEL: 8 ppm diet 1000 1 4E-4
and relative kidney (0.4 mg/kg/day) mg/kg/day
weights in males
LEL: 64 ppm diet
13-Week Rat Feeding (3.2 mg/kg/day)
Study
Hoescht AG, 1982a
*Conversion Factors: 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)
___I.A.2. PRINCIPAL AND SUPPORTING STUDIES (ORAL RfD)
Hoescht AG. 1982a. MRID No. 00142443. Available from EPA. Write to FOI,
EPA, Washington, DC 20460.
Twenty rats/sex/dose were fed diets containing 0, 8, 64, 500 or 4000 ppm of
HOE 39866 (monoammonium 2-amino-4-[hydroxymethylphosphinyl]butanoate) for 13
weeks. An additional 10 rats/sex/dose were similarly treated, but were
allowed a 4-week recovery period. An increase in absolute and relative kidney
weights was noted in males treated with 64 ppm and above.
___I.A.3. UNCERTAINTY AND MODIFYING FACTORS (ORAL RfD)
UF -- An uncertainty factor of 100 was used to account for intra- and
interspecies differences in sensitivity. An additional factor of 10 was used
because the study was only of 90 days duration.
MF -- None
___I.A.4. ADDITIONAL COMMENTS (ORAL RfD)
The 90-day feeding study using dogs (NOEL = 16 ppm, equivalent to 0.4
mg/kg/day) is considered as co-principal.
Data Considered for Establishing the RfD:
1) 13-Week Feeding - rat: Principal study - see previous description; core
grade minimum
2) 90-Day Feeding - dog: NOEL=16 ppm (0.4 mg/kg/day); LEL=64 ppm (1.6
mg/kg/day) (decreased weight gain, decreased absolute and relative thyroid
weights in females); core grade minimum (Hoechst AG, 1982b)
3) Teratology - rat: Developmental NOEL=2.24 mg/kg/day; LEL=10 mg/kg/day
(dilated renal pelvis and hydroureter); Maternal NOEL=2.24 mg/kg/day; LEL=10
mg/kg/day (hyperactivity); core grade minimum (Hoechst AG, 1985a)
4) Teratology - rat: Developmental NOEL = none; LEL=10 mg/kg/day (dilated
renal pelvis and hydroureter); Maternal NOEL=none; LEL=10 mg/kg/day
(hyperactivity); core grade supplementary (Hoechst AG, 1985b)
Data Gap(s): Chronic Dog Feeding Study; Chronic Rat Feeding Study; Rat
Reproduction Study; Rabbit Teratology Study
___I.A.5. CONFIDENCE IN THE ORAL RfD
Study -- High
Data Base -- Medium
RfD -- Medium
The principal study is of good quality and is given a high confidence rating.
Since the data base on chronic toxicity and reproduction is incomplete,
confidence in the data base can be considered medium to low. Confidence in
the RfD can also be considered medium to low.
___I.A.6. EPA DOCUMENTATION AND REVIEW OF THE ORAL RfD
Source Document -- This assessment is not presented in any existing U.S. EPA
document.
Other EPA Documentation -- Pesticide Registration files
Agency Work Group Review -- 02/18/1987
Verification Date -- 02/18/1987
___I.A.7. EPA CONTACTS (ORAL RfD)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- Glufosinate-ammonium
CASRN -- 77182-82-2
Primary Synonym -- Hoe 39866
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- Glufosinate-ammonium
CASRN -- 77182-82-2
Primary Synonym -- Hoe 39866
This substance/agent has not undergone a complete evaluation and determination
under US EPA's IRIS program for evidence of human carcinogenic potential.
_VI. BIBLIOGRAPHY
Substance Name -- Glufosinate-ammonium
CASRN -- 77182-82-2
Primary Synonym -- Hoe 39866
Last Revised -- 09/01/1990
__VI.A. ORAL RfD REFERENCES
Hoescht AG. 1982a. MRID No. 00142443. Available from EPA. Write to FOI,
EPA, Washington, DC 20460.
Hoescht AG. 1982b. MRID No. 00149239. Available from EPA. Write to FOI,
EPA, Washington, DC 20460.
Hoescht AG. 1985a. MRID No. 00151499. Available from EPA. Write to FOI,
EPA, Washington, DC 20460.
Hoescht AG. 1985b. MRID No. 00151500. Available from EPA. Write to FOI,
EPA, Washington, DC 20460.
__VI.B. INHALATION RfD REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
None
_VII. REVISION HISTORY
Substance Name -- Glufosinate-ammonium
CASRN -- 77182-82-2
Primary Synonym -- Hoe 39866
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
09/01/1990 I.A. Principal study citation year corrected
09/01/1990 I.A.4. Citations added
09/01/1990 VI. Bibliography on-line
05/01/1992 I.A. Oral RfD summary noted as pending change
VIII. SYNONYMS
Substance Name -- Glufosinate-ammonium
CASRN -- 77182-82-2
Primary Synonym -- Hoe 39866
Last Revised -- 09/30/1987
77182-82-2
Basta
Caswell No. 580I
EPA Pesticide Chemical Code 128850
Glufosinate-ammonium
HOE 00661
Hoe 39866
Monoammonium-2-amino-4-(hydroxymethylphosphinyl)butanoate
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0247.HTM
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